He's also the first player ranked outside the top 100 to beat the World No. 1 man since 1992.
The second-seeded Nadal has appeared in five finals at the All England Club. But he lost in the second round in 2012 and the first round in 2013.
In another surprising development, former Wimbledon singles and doubles champion Serena Williams was unable to compete with her sister Venus in their doubles match. Serena Williams looked out of sorts, unable to catch the ball when it was tossed to her and at times unable to serve. Wimbledon officials said after the match that Williams was suffering from a virus.
The sisters pulled out of the match after only three games. Serena, who lost in singles Saturday, was looked at by members of the medical staff who checked her blood pressure before the doubles match even began. At love-40, the umpire took the unusual step of climbing down from the chair and walking over to speak to Serena. She then served another double-fault to trail 3-0.
And French Open champion and fifth seed Maria Sharapova has been ousted. She lost in three sets to ninth seed Angelique Kerber of Germany 7-6, 4-6, 6-4. Sharapova, a five-time major champion, had lost only seven games in her three previous matches at the All England Club this year. Kerber reached the semifinals at Wimbledon in 2012.
In other results, French Open runner-up Simona Halep breezed into the quarterfinals with a straight sets win over an unseeded player. Halep, who has reached the quarterfinals at all three Grand Slams this year, is the only player among the top four seeds left in the draw.
She will face Sabine Lisicki next as the 2013 finalist, who overcame shoulder trouble, advanced with a three-set win over another unseeded player. The 19th-seeded Lisicki took an injury timeout while facing break point at 1-1 in the second set and was treated by a trainer on her right shoulder.
Seven-time champion Roger Federer returned to the quarterfinals with a clinical 6-1, 6-4, 6-4 victory over Tommy Robredo of Spain. The fourth-seeded Federer looked in complete control and saved the only break point he faced in the final game of the match with a forehand volley. He has yet to lose a set at the All England Club this year. And fifth-seed Stan Wawrinka has advanced with a straight sets win over 19th-seed Feliciano Lopez. He will face Federer in the next round of play.